Abivertinib maleate CAS:1557268-88-8

Abivertinib,also known as avitinib,AC0010 or AC0010MA,is an orally available, irreversible,epidermal growth factor receptor(EGFR)mutant-selective inhibitor, with potential antineoplastic activity.Upon oral administration,avitinib covalently binds to and inhibits the activity of mutant forms of EGFR,including the drug-resistant T790M EGFR mutant,which prevents signaling mediated by mutant forms of EGFR.This may both induce cell death and inhibit tumor growth in EGFR-mutated tumor cells.EGFR,a receptor tyrosine kinase that is mutated in a variety of cancers,plays a key role in tumor cell proliferation and tumor vascularization.As this agent is selective towards mutant forms of EGFR,its toxicity profile may be reduced when compared to non-selective EGFR inhibitors, which also inhibit wild-type EGFR.

msds---Abivertinib maleate